The precision in synaptic matchmaking at the
Drosophila neuromuscular system is ultimate, it displays a one-to-one single cell resolution. How the neurons and muscles accomplish this astounding precision is still a major challenge to neurobiology. However, our observations may shed some light into this process in vivo. Using three- and four-dimensional analysis in undissected, live
Drosophila embryos expressing GFP-based bioprobes, we have observed highly animated actin-based micro processes (
myopodia) that extend from muscle cells before neuromuscular synaptogenesis. This part of my research program is designed to understand the underlying cellular behavioral pattern of myopodia... <
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